Route 66 is one of the most famous highways in the United States. Missouri is home to more than 280 miles of the "Mother Road," and features some of the Route's most historic tourist attractions. As you travel Route 66, we recommend taking the "scenic route" and spending a few days to cover a handful of the things to do on Route 66 in Missouri. Begin your journey from St. Louis, one of the most popular cities on Route 66.