Welcome to Our Cape Girardeau Hotel. Just off I-55 at exit 96, the Holiday Inn Express Hotel & Suites Cape Girardeau I-55 offers hotel guests 102 spacious, contemporary suites. Vacation and business guests alike choose these accommodations for a comfortable and convenient stay.
Our Cape Girardeau, Missouri hotel is just minutes from Southeast Missouri State University, where guests are encouraged to cheer on the Redhawks in football and basketball. We're also only 10 miles from Trail of Tears State Park, so families can enjoy picnics, hiking, biking and fishing. Be sure to stop by our Old Downtown area where you will not only enjoy a variety of shops and restaurants, but you can enjoy the great view of the Mississippi River.
Business travelers appreciate our Cape Girardeau, Missouri hotel's convenient location close to St. Francis Hospital, Southeast Missouri Hospital, Doctors Park, the Show Me Center, Procter & Gamble, Mondi, and Shawnee Park.