Book now at the Sleep Inn & Suites hotel in Hannibal, MO. This smoke-free, pet-friendly hotel is conveniently located off I-72 near Hannibal Regional Hospital, Hannibal Regional Airport and Mark Twain's Boyhood Home. Amenities include free hot breakfast, free Wi-Fi, an indoor heated pool, an exercise room and guest laundry facilities. All guest rooms feature microwaves, refrigerators, hairdryers and 39-inch flat-screen TVs. Whether traveling to Hannibal, MO for business or leisure, the Sleep Inn & Suites has everything you need. Book today!