Places to Stay

Holiday Inn St. Louis SW – Route 66

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Get Your Kicks on Route 66!  With a convenient location along Historic Route 66 in Sunset Hills, the Holiday Inn St. Louis SW – Route 66 offers the best accommodations in town.  At the junction of I-44 and I-270, the hotel is located less than two miles from Historic Kirkwood, and just 14 miles from the Gateway Arch and all the exciting attractions downtown St. Louis has to offer.

Stay and play in St. Louis and experience a Cardinals game at Busch Stadium, a Blues game at Enterprise Arena, or come show your support for one of your most favorite traveling teams at the World Wide Technology Soccer Park.  A visit to St. Louis wouldn’t be complete without a stop by the ever-so-popular St. Louis Science Center, St. Louis Aquarium, Missouri Botanical Gardens, Magic House, Six Flags, or the nationally accredited St. Louis Zoo.  The hotel is also just a short drive to Webster University, Harris-Stowe State University, St. Louis University, Barnes Jewish Hospital, St. Louis Children’s Hospital, Mercy Hospitals, SSM, and Washington University’s top medical centers.

Corporate and leisure travelers will be impressed with our newly renovated 213-room hotel and 15,500 square feet of flexible meeting space.  Sunset Event Space, operated by Twisted Catering, will be the place to host meetings, weddings, and special events for years to come. Guests can also enjoy “Wakey Wakey a Breakfast Place” for a fresh start to the day, and lunch or dinner at the Award-Winning Twisted Tree Steakhouse adjacent to the hotel.


10709 Watson Road
St. Louis, MO 63127

Additional Information

Travelers With Disabilities Information
ADA Fully Compliant
Braille Signage
Wheelchair Accessible
Special Needs Accommodations
Smoking Policy
No Smoking
Activities Within 10 Miles
Historic District
Biking / Walking Trails
General Interest Info
ATM Available
Gift / Souvenir Shop
Open Year-round
Restaurant On-site
Wi-Fi Available
Group Policy
Advance Contact Required
Guest Reservations Needed?
Reservations Required
Pet Policy
Pets Allowed / Additional Fee
Suitable For These Age Groups
Family Friendly
Types Of Payment Accepted
American Express Card
On-site Amenities
Bar / Lounge
Bicycle Parking / Storage
Business Center
Fitness Center
Hot Breakfast
RV / Bus Parking
Outdoor Pool
Laundry Facilities
Hotel Restaurant
Room Amenities
Coffee Maker
Wi-Fi (no Charge)
Cable / Satellite TV
Room Rates
Low Rate (per Day) $99
High Rate (per Day) $199