The hotel, listed on the National Register of Historic Places, was renovated as a hotel in 2006. The Saint George features 25 guestrooms, a restaurant, cafe, lounge and the National Silk Art Museum.

The Saint George Hotel originated in 1845 as a three-story structure with 47 rooms on the top two floors. Billed as a working man's hotel, the first floor provided a saloon, sample rooms, a tobacco shop, a restaurant, and two retail spaces. Following the Civil War, and the floods of 1858 and 1881, the hotel lost much of its business, but the building persevered, operating as apartments, a post office and bank.